吴长锋

教授

生物医学工程创新中心

E-mail: [email protected]
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       获得国家自然科学优秀青年基金，博士生导师，中国生物医学工程学会生物光子学分会委员。在国际上率先开展半导体聚合物荧光量子点 (Polymer Dot) 的研究，近十年来在聚合物量子点的制备表征、能量传递、单粒子荧光、性能调控、和生物医学应用等方面取得了多项原创性学术成果。迄今共发表SCI 收录论文75 篇，包括在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv.Mater., ACS Nano 等影响因子大于10 的期刊上发表论文18 篇，被包括Nature、Science、Nature 子刊、Chemical Reviews、Chemical Society Reviews在内的学术期刊总共引用4000多次，其中单篇引用超过100 次的论文15 篇，当前H因子为32。

教育和工作经历:

1994-1998 齐鲁工业大学材料科学与工程学院 本科

1998-2001 吉林大学材料科学与工程学院 硕士

2001-2004 中科院长春光机与物理研究所 凝聚态物理博士

2004-2005 美国Clemson 大学物理系 生物光学博士后

2005-2008 美国Clemson 大学化学系 物理化学博士

2008-2012 美国华盛顿大学化学系 生物分析博士后

2012-2016 吉林大学电子科学与工程学院 教授、博士生导师

2016年-至今 南方科技大学生物医学工程系 教授

项目负责人:

2012 年 国家自然科学优秀青年基金项目“生物医学光子学”

2013 年 国家自然科学基金重点项目“开关/闪烁可控聚合物量子点的设计制备及纳米分辨动态光学成像研究”

发表论文:

1. Sun, K.; Tang, Y.; Li, Q.; Yin, S.; Qin, W.; Yu, J.; Chiu, D. T.; Liu, Y.; Yuan, Z.; Zhang,X.; Wu, C.* In Vivo Dynamic Monitoring of Small Molecules with Implantable Polymer-Dot Transducer. ACS Nano 2016, 6, 6769-6781.

2. Chang, K.; Tang, Y.; Liu, Z.; Fang, X.; Yin, S.; Xu, H.; Wu, C.* Incorporation of Porphyrin to π‑Conjugated Backbone for Polymer-Dot-Sensitized Photodynamic Therapy. Biomacromolecules 2016, 17, 2128-2136.

3. Sun, Z.; Liu, S.; Liu, Z.; Qin, W.; Chen, D.; Xu, G.; Qin, W.; Wu, C.* FRET Acceptor Suppressed Single-Particle Photobleaching in Semiconductor Polymer Dots.Optics Letters 2016, 41, 2370-2373.

4. Li, S.; Chang, K.; Sun, K.; Tang, Y.; Cui, N.; Wang, Y.; Qin, W.; Xu, H.; Wu, C.* Amplified Singlet Oxygen Generation in Semiconductor Polymer Dots for Photodynamic Cancer Therapy. ACS Applied Materials & Interfaces 2016, 8,3624-3634.

5. Liu, Z.; Sun, Z.; Di, W.; Qin, W.; Yuan, Z.; Wu, C.* Brightness calibrates particle size in single particle fluorescence imaging. Optics Letters 2015, 40, 1242-1245.

6. Chen, H.; Chang, K.; Men, X.; Sun, K.; Fang, X.; Ma, C.; Zhao, Y.; Yin, S.; Qin, W.;Wu, C.* Covalent Patterning and Rapid Visualization of Latent Fingerprints with Photo-Cross-Linkable Semiconductor Polymer Dots. ACS Applied Materials &Interfaces 2015, 7, 14477-14484.

7. Chang, K.; Men, X.; Chen, H.; Liu, Z.; Yin, S.; Qin, W.; Yuan, Z.; Wu, C.*Silica-encapsulated semiconductor polymer dots as stable phosphors for white light-emitting diodes. Journal of Materials Chemistry C 2015, 3, 7281-7285.

8. Zhang, Y.; Chang, K.; Xu, B.; Chen, J.; Yan, L.; Ma, S.; Wu, C.*; Tian, W.* Highly efficient near-infrared organic dots based on novel AEE fluorogen for specific cancer cell imaging. RSC Advances 2015, 5,36837-36844.

9. Sun, C.; Zhang, Y.*; Sun, K.; Reckmeier, C.; Zhang, T.; Zhang, X.; Zhao, J.; Wu, C.*;Yu, W. W.; Rogach, A. L. Combination of carbon dot and polymer dot phosphors for white light-emitting diodes. Nanoscale 2015, 7, 12045-12050.

10. Li, S.; Chen, J.; Chen, G.; Li, Q.; Sun, K.; Yuan, Z.; Qin, W.; Xu, H.*; Wu, C.*,Semiconductor Polymer Dots Induce Proliferation in Human Gastric Mucosal and Adenocarcinoma Cells. Macromolecular Bioscience 2015, 15, 318-237.

11. Sun, K.; Chen, H.; Wang, L.; Yin, S.; Wang, H.; Xu, G.; Chen, D.; Zhang, X.; Wu, C.*;Qin, W.*, Size-dependent property and cell labeling of semiconducting polymer dots. ACS Applied Materials & Interfaces 2014, 6, 10802-10812.

12. Li, Q.; Zhang, J.; Sun, W.; Yu, J.; Wu, C.*; Qin, W.*; Chiu, D. T.*,Europium-Complex-Grafted Polymer Dots for Amplified Quenching and Cellular Imaging pplications. Langmuir 2014, 30, 8607-8614.13. Chang, K.; Liu, Z.; Chen, H.; Sheng, L.; Zhang, S. X. A.; Chiu, D. T.; Yin, S.; Wu, C.*;Qin, W.*, Conjugated Polymer Dots for Ultra‐Stable Full‐Color Fluorescence Patterning. Small 2014, 10, 4270-4275.

14. Li, Q.; Sun, K.; Chang, K.; Yu, J.; Chiu, D. T.; Wu, C.*; Qin, W.*, Ratiometric Luminescent Detection of Bacterial Spores with Terbium Chelated Semiconducting Polymer Dots. Analytical Chemistry 2013, 85, 9087-9091.

15. Wu, C.; Chiu, D. T., Highly fluorescent semiconducting polymer dots for biology and medicine (Invited Review). Angewandte Chemie International Edition 2013,52, 3086-3109.

16. Wu, C.; Hansen, S. J.; Hou, Q.; Yu, J.; Zeigler, M.; Jin, Y.; Burnham, D. R.; McNeill,J. D.; Olson, J. M.; Chiu, D. T., Design of highly emissive polymer dot bioconjugates for in vivo tumor targeting. Angewandte Chemie International Edition 2011, 50, 3430-3434.

17. Wu, C.; Schneider, T.; Zeigler, M.; Yu, J.; Schiro, P. G.; Burnham, D. R.; McNeill, J.D.; Chiu, D. T., Bioconjugation of ultrabright semiconducting polymer dots for specific cellular targeting. Journal of the American Chemical Society 2010, 132,15410-15417.

18. Wu, C.; Jin, Y.; Schneider, T.; Burnham, D. R.; Smith, P. B.; Chiu, D. T.,Ultrabright and bioorthogonal labeling of cellular targets using semiconducting polymer dots and click chemistry. Angewandte Chemie International Edition 2010,49, 9436-9440.

19. Wu, C.; Bull, B.; Christensen, K.; McNeill, J., Ratiometric Single‐Nanoparticle Oxygen Sensors for Biological Imaging. Angewandte Chemie International Edition 2009, 48, 2741-2745.

20. Wu, C.; Zheng, Y.; Szymanski, C.; McNeill, J., Energy transfer in a nanoscale multichromophoric system: fluorescent dye-doped conjugated polymer nanoparticles. The Journal of Physical Chemistry C 2008, 112, 1772-1781.

21. Wu, C.; Bull, B.; Szymanski, C.; Christensen, K.; McNeill, J., Multicolor conjugated polymer dots for biological fluorescence imaging. ACS Nano 2008, 2, 2415-2423.

22. Wu, C.; McNeill, J., Swelling-controlled polymer phase and fluorescence properties of polyfluorene nanoparticles. Langmuir 2008, 24, 5855-5861.

23. Wu, C.; Szymanski, C.; Cain, Z.; McNeill, J., Conjugated polymer dots for multiphoton fluorescence imaging. Journal of the American Chemical Society 2007, 129, 12904-12905.

24. Wu, C.; Szymanski, C.; McNeill, J., Preparation and encapsulation of highly fluorescent conjugated polymer nanoparticles. Langmuir 2006, 22, 2956-2960.

25. Wu, C.; Peng, H.; Jiang, Y.; McNeill, J., Energy transfer mediated fluorescence from blended conjugated polymer nanoparticles. The Journal of Physical Chemistry B 2006, 110, 14148-14154.

26. Wu, C.; Liang, X.; Jiang, H., Metal nanoshells as a contrast agent in near-infrared diffuse optical tomography. Optics Communications 2005, 253, 214-221.

27. Wu, C.; Barnhill, H.; Liang, X.; Wang, Q.; Jiang, H., A new probe using hybrid virus-dye nanoparticles for near-infrared fluorescence tomography. Optics Communications 2005, 255, 366-374.

28. Wu, C.; Qin, W.; Qin, G.; Zhao, D.; Zhang, J.; Xu, W.; Lin, H., Spontaneous growth and luminescence of Si/SiO x core-shell nanowires. Chemical Physics Letters 2003, 378, 368-373.

29. Wu, C.; Qin, W.; Qin, G.; Zhao, D.; Zhang, J.; Huang, S.; Lü, S.; Liu, H.; Lin, H.,Photoluminescence from surfactant-assembled Y2O3: Eu nanotubes. Applied Physics Letters 2003, 82, 520-522.

30. Wu, C.; Qin, W.; Qin, G.; Huang, S.; Zhang, J.; Zhao, D.; Lü, S.; Liu, H.,Near-infrared-to-visible photon upconversion in Mo-doped rutile titania.Chemical Physics Letters 2002, 366, 205-210.